When rag doll 9 first comes to life, he finds himself in a post-apocalyptic world where all humans are gone. It is only by chance that he discovers a small community of others like him taking refuge from fearsome machines that roam the earth intent on their extinction. Despite being the newest member of the group, 9 convinces the others that hiding will do them no good. They must take the offensive if they are to survive and they will need to discover...

Years after the Raccoon City disaster, Alice is on her own. She is aware that she has become a liability and could endanger those around her and she struggles to survive and bring down the Umbrella Corporation led by the sinister Albert Wesker and head researcher Dr. Isaacs. Meanwhile, traveling through the Nevada Desert and the ruins of Las Vegas, Carlos Olivera, L.J., and new survivors K-Mart, Claire Redfield, and Nurse Betty must fight to survive...