Will Graham is an FBI agent who brought Hannibal Lecter to justice; however, his confrontation with Lecter proved to be a bloody, near-death experience. Retiring from the Bureau, he moves to Florida. However, a particularly grisly killer is on the loose, and Jack, Graham's one-time mentor at the Bureau, asks him to return to duty to find him. "The Tooth Fairy" is a vicious murderer who kills entire families at once, covering the eyes of his victims...

After young Hannibal is forced to watch his little sister, Mischa, being devoured by starving soldiers in his Lithuania homeland. Hannibal vows to avenge his sister's death by slaying those who committed not only war crimes against the Lecters, but also against other families during WW II. Hannibal's revenge plan includes his cannibalism to justify his insatiable appetite for human flesh. Hannibal excels in his medical school classes dissecting cadavers....

Hannibal is on the run in Europe, accompanied by his psychiatrist, Bedelia Du Maurier, sporting a new identity, but servicing the same insatiable appetite. As the lives of Will and Jack converge toward Hannibal again, each with their own motivations to catch him once and for all, their deadly dance turns in startling and unexpected ways.