When his newborn son by his second wife is diagnosed with high-risk neuroblastoma, New York City forensic pathologist Jack Stapleton seeks to find a cure for his son while at the same time being drawn into a battle between the archbishop of New York and an archeologist--a battle involving what some people believe to be the skeletal remains the Virgin Mary.

After a young, seemingly healthy woman collapses suddenly on the NYC subway and dies by the time she reaches the hospital, her case is initially chalked up to a virulent strain of influenza. That is, until she ends up on Dr. Jack Stapleton's autopsy table, where Jack discovers something eerily fishy: first, that the young woman has had a heart transplant, and second, that her DNA matches that of the transplanted heart. Strangely, two more incidences...

"Due to Jack Stapleton's ongoing recovery from his near-death confrontation with a serial killer, his wife Laurie Montgomery, the NYC chief medical examiner, is carrying the load both at work and at home. When she insists an underperforming pathology resident named Ryan Sullivan assist her on a suicide autopsy, Laurie unknowingly provokes an emotional storm in the trainee. So, when Ryan himself appears on the medical examiner's table days later,...